Lessons Learned from Development of a Software Tool to Support Academic Advising

We detail some lessons learned while designing and testing a decision-theoretic advising support tool for undergraduates at a large state university. Between 2009 and 2011 we conducted two surveys of over 500 students in multiple majors and colleges. These surveys asked students detailed questions about their preferences concerning course selection, advising, and career paths. We present data from this study which may be helpful for faculty and staff who advise undergraduate students. We find that advising support software tools can augment the student-advisor relationship, particularly in terms of course planning, but cannot and should not replace in-person advising.Comment: 5 Figures, revised version including more figures and cross-referencin

Collection and analysis of a global marine phytoplankton primary-production dataset

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A Robust Filter for the BeppoSAX Gamma Ray Burst Monitor Triggers

The BeppoSAX Gamma Ray Burst Monitor (GRBM) is triggered any time a statistically significant counting excess is simultaneously revealed by at least two of its four independent detectors. Several spurious effects, including highly ionizing particles crossing two detectors, are recorded as onboard triggers. In fact, a large number of false triggers is detected, in the order of 10/day. A software code, based on an heuristic algorithm, was written to discriminate between real and false triggers. We present the results of the analysis on an homogeneous sample of GRBM triggers, thus providing an estimate of the efficiency of the GRB detection system consisting of the GRBM and the software.Comment: Proc. 5th Huntsville GRB Symposiu

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

Autophagy is usually a pro-survival mechanism in cancer cells, especially in the course of chemotherapy, thus autophagy inhibition may enhance the chemotherapy-mediated anti-cancer effect. However, since autophagy is strongly involved in the immunogenicity of cell death by promoting ATP release, its inhibition may reduce the immune response against tumors, negatively influencing the overall outcome of chemotherapy. In this study, we evaluated the in vitro and in vivo anti-cancer effect of curcumin (CUR) against Her2/neu overexpressing breast cancer cells (TUBO) in the presence or in the absence of the autophagy inhibitor chloroquine (CQ). We found that TUBO cell death induced by CUR was increased in vitro by CQ and slightly in vivo in nude mice. Conversely, CQ counteracted the Cur cytotoxic effect in immune competent mice, as demonstrated by the lack of in vivo tumor regression and the reduction of overall mice survival as compared with CUR-treated mice. Immunohistochemistry analysis revealed the presence of a remarkable FoxP3 T cell infiltrate within the tumors in CUR/CQ treated mice and a reduction of T cytotoxic cells, as compared with single CUR treatment. These findings suggest that autophagy is important to elicit anti-tumor immune response and that autophagy inhibition by CQ reduces such response also by recruiting T regulatory (Treg) cells in the tumor microenvironment that may be pro-tumorigenic and might counteract CUR-mediated anti-cancer effects

Further insights on predictors of environmental tobacco smoke exposure during the pediatric age

Background: The smoking ban in public places has reduced Environmental Tobacco Smoke (ETS) exposure for non-smokers, but despite this, domestic environments still remain places at high risk of exposure, and, today, about 40% of children worldwide are exposed to ETS at home. The aims of the study are to investigate the contribution of several factors on ETS exposure among a group of Italian children and to evaluate the changes in smoking precautions adopted at home when the smoker is the mother, the father, or both parents, respectively. Methods: A cross-sectional study was performed on a sample of 519 Italian schoolchildren. Information was collected via a questionnaire. Results: 41.4% of the participants lived with at least one smoker. Almost half of the children exposed to ETS lived with one or more smokers who do not observe any home smoking ban. Lower maternal or paternal educational levels significantly increase the risk of ETS exposure at home and the “worst case” is represented by both parents who smoke. Conclusions: More effective preventive interventions are needed to protect children from ETS exposure. Some interventions should be specifically dedicated to smokers with a low educational level and to mothers that smoke

Anomalous cooling of the massive white dwarf in U Geminorum following a narrow dwarf nova outburst

We obtained Hubble GHRS medium resolution (G160M grating) phase-resolved spectroscopic observations of the prototype dwarf nova U Geminorum during dwarf nova quiescence, 13 days and 61 days following the end of a narrow outburst. The spectral wavelength ranges were centered upon three different line regions: N V (1238\AA, 1242\AA), Si III (1300\AA) and He II (1640\AA). All of the quiescent spectra at both epochs are dominated by absorption lines and show no emission features. The Si III and He II absorption line velocities versus orbital phase trace the orbital motion of the white dwarf but the N~V absorption velocities appear to deviate from the white dwarf motion. We confirm our previously reported low white dwarf rotational velocity, V sin i= 100 km/s. We obtain a white dwarf orbital velocity semi-amplitude K1=107 km/s. Using the gamma-velocity of Wade (1981) we obtain an Einstein redshift of 80.4 km/s and hence a carbon core white dwarf mass of ~1.1 Msun. We report the first subsolar chemical abundances of C and Si for U Gem with C down by 0.05 with respect to the Sun, almost certainly a result of C depletion due to thermonuclear processing. This C-depletion is discussed within the framework of a weak TNR, contamination of the secondary during the common envelope phase, and mixing of C-depleted white dwarf gas with C-depleted matter deposited during a dwarf nova event. Remarkably the Teff of the white dwarf 13 days after outburst is only 32,000K, anomalously cooler than previous early post-outburst measurements. Extensive cooling during an extraordinarily long (210 days) quiescence followed by accretion onto an out-of-equilibrium cooled degenerate could explain the lower Teff.Comment: 16 pages AAS-Latex, 4 Figures, accepted for publication in Ap